Cyclophosphamide in exacerbations of multiple sclerosis. Therapeutic trial and a strategy for pilot drug studies.
| Autor: | Drachman, D A, Paterson, P Y, Schmidt, R T, Spehlmann, R F |
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| Předmět: |
ANIMAL experimentation
BALDNESS BIOLOGICAL models CLINICAL trials COMPARATIVE studies CYSTITIS DEMYELINATION DRUG design CLINICAL drug trials IMMUNOLOGY technique RESEARCH methodology MEDICAL cooperation MULTIPLE sclerosis NAUSEA RATS RESEARCH PILOT projects EVALUATION research ACUTE diseases CYCLOPHOSPHAMIDE |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry; Jun1975, Vol. 38 Issue 6, p592-597, 6p |
| Abstrakt: | Cyclophosphamide (CY) has been shown to reverse the signs of experimental allergic encephalomyelitis (EAE) even after the onset of neurological deficits. Because of the analogy of EAE to exacerbations of multiple sclerosis (MS) a clinical trial of CY in acute MS exacerbations was undertaken. A 'sequential criterion' method was used to minimize the size of sample needed for this pilot study. CY failed to alter significantly the course of acute exacerbations of MS. Possible reasons for this failure, and the value of the sequential criterion method in pilot studies, are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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