Deficiencies in anti-acetylcholine receptor antibody measurement in myasthenia gravis.

Autor: Clarke, C E, Shepherd, D I, Yuill, G M, Smaje, J C, Wilson, P B
Předmět:
Zdroj: Journal of Neurology, Neurosurgery & Psychiatry; May1991, Vol. 54 Issue 5, p454-456, 3p
Abstrakt: In a retrospective case note study of 86 patients with myasthenia gravis, 60 had an anti-acetylcholine receptor antibody assay performed by the regional immunology laboratory. Antibody was detected in 38% which compares with 66-93% in other series. Whilst the use of staphylococcal protein A to precipitate the antibody-receptor complex, rather than anti-human immunoglobulin, may be partly responsible for this low sensitivity, other methodological problems are likely to exist. It is suggested that this potentially critical assay becomes a subject for regular audit. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index