| Autor: |
Meyler, W J, Bakker, H, Kok, J J, Agoston, S, Wesseling, H |
| Zdroj: |
Journal of Neurology, Neurosurgery & Psychiatry; Apr1981, Vol. 44 Issue 4, p334-339, 6p |
| Abstrakt: |
In 25 patients with spasticity, pharmacokinetics and effects of dantrolene sodium were investigated after prolonged administration. A beneficial effect occurred in seven patients. The results were better on 100 mg daily than on a higher daily dose. An increase of the daily dose from 200 to 400 mg was not associated with higher blood levels. Many side effects were noted such as: anorexia, nausea, drowsiness, depression and muscle weakness. From this study we conclude that dantrolene sodium is a muscle relaxant with a weak to moderate effect in patients with spasticity; the effect at doses higher than 200 mg daily is probably poor. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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