Decreased platelet 3H-imipramine binding sites in classical migraine.

Autor: Geaney, D P, Rutterford, M G, Elliott, J M, Schächter, M, Peet, K M, Grahame-Smith, D G
Zdroj: Journal of Neurology, Neurosurgery & Psychiatry; Jul1984, Vol. 47 Issue 7, p720-723, 4p
Abstrakt: Patients with classical migraine investigated between attacks had significantly fewer platelet 3H-imipramine binding sites than control subjects and this finding was more marked in males than in females. There was no abnormality of binding characteristics of platelet 5-hydroxytryptamine receptors or of platelet alpha 2-adrenoceptors. Because the reduced 3H-imipramine binding capacity was found in classical migraineurs who were investigated between attacks, it may reflect a predisposition to migraine rather than being a consequence of attacks. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index