The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues.

Autor: Tagari, P C, Kaye, A H, Teddy, P J, Schachter, M, Adams, C B, Boullin, D J
Zdroj: Journal of Neurology, Neurosurgery & Psychiatry; Mar1983, Vol. 46 Issue 3, p214-220, 7p, 3 Charts, 4 Graphs
Abstrakt: Peri-aneurysmal CSF was obtained at operation from 13 patients with subarachnoid haemorrhage from ruptured intracranial aneurysms. The 5-hydroxytryptamine antagonist ketanserin inhibited contractions of isolated human intracranial arteries, elicited by this CSF. The presence of 5-HT in CSF was confirmed by high performance liquid chromatography. The use of ketanserin in the therapy of postoperative cerebral vasospasm is discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index