| Autor: |
Chai, B. C., Etches, W. S., Stewart, M. W., Siminoski, K. |
| Předmět: |
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| Zdroj: |
Postgraduate Medical Journal; Feb1996, Vol. 72 Issue 844, p113-114, 2p, 1 Chart |
| Abstrakt: |
We describe a man with adrenoleukodystrophy receiving Lorenzo's oil (glycerol trioleate and glycerol trierucate) who developed purpura, petechiae, and bleeding. Bleeding time was markedly increased (>20 min), although he had only borderline thrombocytopenia (120 x 10(9)/1) and conventional platelet aggregation studies were normal (except for a borderline response to low concentration collagen), as were results using a new technique employing immobilised von Willebrand factor. Together these results suggest that bleeding in this man resulted from a defect in vascular wall function or in the interaction of platelets with the endothelium. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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