| Autor: |
Rutland, M. D., Lee, T. Y., Nimmon, C. C., Granowska, M., Britton, K. E. |
| Zdroj: |
Postgraduate Medical Journal; Dec1980, Vol. 56 Issue 662, p818-822, 5p, 3 Charts |
| Abstrakt: |
It was considered that the first dose reaction occurring with prazosin may have been due either to hypotension or to a specific reduction in cerebral blood flow. The development of a quantitative non-invasion nuclear medicine technique for cerebral flow has now made it possible to investigate the effects of prazosin on cerebral blood flow in hypertensive patients. This double-blind study showed a significant decrease in BP and a small just significant increase in cerebral blood flow following a single 1-mg dose of prazosin, when compared with a placebo. From these results, it is unlikely that the first dose reactions which occurred with prazosin were due to a specific reduction in cerebral blood flow. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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