Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin.

Autor: Quesne, Pamela M. Le, Goldberg, Valerie, Vajda, F.
Zdroj: Journal of Neurology, Neurosurgery & Psychiatry; Oct1976, Vol. 39 Issue 10, p995-1000, 6p
Abstrakt: Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index