Convenient Synthesis of 3-Methylcoumarins and Coumarin-3-carbaldehydes.

Autor: Olomola, TemitopeO., Klein, Rosalyn, Kaye, PerryT.
Předmět:
Zdroj: Synthetic Communications; 2012, Vol. 42 Issue 2, p251-257, 7p, 2 Diagrams
Abstrakt: Rapid, microwave-assisted Baylis-Hillman reactions of substituted salicylaldehydes, followed by one-pot hydrogen iodide-mediated cyclization and reduction of the corresponding adducts, has afforded 3-methylcoumarins in up to 94% yield in the final step. Subsequent microwave-assisted selenium dioxide oxidation of selected 3-methylcoumarins has provided convenient access to the corresponding coumarin-3-carbaldehydes and permitted a significant improvement over the yield obtained using conventional heating. [image omitted] [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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