Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficileribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unitThis article is part of the ChemComm‘Glycochemistry and glycobiology’ web themed issue.Electronic supplementary information (ESI) available: Experimental details and full spectroscopic data for all new compounds. See DOI: 10.1039/c1cc13614c

Autor:	Martin, Christopher E., Weishaupt, Markus W., Seeberger, Peter H.
Předmět:	CARBOHYDRATES VACCINES CLOSTRIDIOIDES difficile CELL membranes POLYSACCHARIDES BIOSYNTHESIS PATHOGENIC microorganisms PREVENTIVE medicine
Zdroj:	Chemical Communications; Sep2011, Vol. 47 Issue 37, p10260-10262, 3p
Abstrakt:	Clostridium difficilestrain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu