| Autor: |
Arikan, Serap, Eren, Orhan, Gencer, Murat, Koseoglu, Hamide Kart |
| Zdroj: |
Cell Membranes & Free Radical Research; Jun2008, Vol. 1 Issue 1, p42-42, 1/3p |
| Abstrakt: |
Chaperones have hitherto been recognised as having only intracellular functions to protect cells from stress by preventing denaturation of proteins and thereby apoptic cell death. Bip (Grp 78) is a key chaperone of endoplasmic reticulum (ER) function due to its roles in protein folding and assembly, targeting misfolded protein for degradation, and controlling the activation of ER stress sensors. ER stress has been suggested to be involved in various diseases, such as diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. Ankylosing Spondylitis (AS) occurs due to misfolding of HLA-B27 protein. This misfolding causes ER stress and this stress trigger autoimmunity. The aim of the present study is to investigate antibodies against BYP which are suggested to present in HLA-B27- associated Ankylosing Spondylitis. Thirty serum samples from patients with Ankylosing Spondylitis and thirty controls were analysed for the presence of Anti BIP by means of Enzyme Ymmunosorbent Assay using method of Bodman. There were no significant differences between patients and controls in the samples. Although HLA-B27associated AS is suggested to cause ER stress, the indirect marker of ER stress anti BIP was absent in our patient group. The mechanism by which Grp78 autoimmunity is triggered or initiated is still remaining unclear. Further investigations are still needed to be performed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
