Associations of Cigarette Smoking and Alcohol Consumption With Advanced or Multiple Colorectal Adenoma Risks: A Colonoscopy-based Case-Control Study in Korea.
| Autor: | Shin, Aesun, Hong, Chang Won, Sohn, Dae Kyung, Chang Kim, Byung, Han, Kyung Su, Chang, Hee Jin, Kim, Jeongseon, Oh, Jae Hwan |
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| Předmět: |
ADENOMA
RECTUM tumors COLON tumors ALCOHOLISM ANALYSIS of variance CHI-squared test COLONOSCOPY CONFIDENCE intervals EPIDEMIOLOGY ETHANOL RESEARCH funding SMOKING LOGISTIC regression analysis DATA analysis CASE-control method DATA analysis software DISEASE risk factors TUMOR risk factors CANCER risk factors |
| Zdroj: | American Journal of Epidemiology; Sep2011, Vol. 174 Issue 5, p552-562, 11p |
| Abstrakt: | The associations between alcohol consumption and cigarette smoking habits and the risk for colorectal adenomatous polyps according to the detailed clinical information about polyps were assessed in a large colonoscopy-based study. The study enrolled participants who visited the National Cancer Center of the Republic of Korea for cancer screening between April 2007 and April 2009. In 1,242 newly diagnosed colorectal adenoma patients and 3,019 polyp-free controls, past smokers (odds ratio (OR) = 1.31, 95% confidence interval (CI): 1.04, 1.65) and current smokers (OR = 1.70, 95% CI: 1.37, 2.11) had increased risks for adenomas compared with nonsmokers. Cigarette smoking conferred an even higher risk for advanced adenomas and 3 or more adenomas than for low-risk adenomas or a single adenoma. Dose-response relations were observed among the daily number of cigarettes smoked, the duration of smoking, the pack-years of smoking, and the risk for adenomas. A longer duration of alcohol consumption was associated with a higher risk for advanced adenomas (for >28 years of consumption: OR = 2.0, 95% CI: 1.10, 3.64) and 3 or more adenomas (OR = 2.19, 95% CI: 1.27, 3.76). In conclusion, cigarette smoking and alcohol consumption play roles in colorectal carcinogenesis, and the association differs by the clinical features of the adenomas. [ABSTRACT FROM PUBLISHER] |
| Databáze: | Complementary Index |
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