β-Actin-derived peptides isolated from acidic extract of rat spleen suppress tumor cell growth.

Autor: Blishchenko, Elena Y., Sazonova, Olga V., Yatskin, Oleg N., Kalinina, Olga A., Tolmazova, Anna G., Philippova, Marina M., Karelin, Andrei A., Ivanov, Vadim T.
Zdroj: Journal of Peptide Science; Jul2008, Vol. 14 Issue 7, p811-818, 8p
Abstrakt: Twenty-two fragments of β-actin and β-actin-related protein were isolated from the acidic extracts of rat spleen tissue. β-Actin fragments (75-90), (78-89), and (78-88), 0.01-1 µ M, decreased live cell number of L929 murine tumor fibroblasts by 80-90%, with maximal cytotoxic effect of 30-40%. The fragments of (78-90) segment and the fragment of β-actin-related protein (69-77) were less active (inhibitory effect up to 55%, cytotoxic-up to 25%). Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index