| Autor: |
Mets, Monique A. J., Kuipers, Esther, Senerpont Domis, Lieke M., Leenders, Maartje, Olivier, Berend, Verster, Joris C. |
| Předmět: |
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| Zdroj: |
Human Psychopharmacology: Clinical & Experimental; Jul2011, Vol. 26 Issue 6, p434-439, 6p, 2 Color Photographs, 3 Charts, 1 Graph |
| Abstrakt: |
Objective The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo. Methods Twenty-seven healthy young adults (14 men and 13 women; mean age (SD) = 22.8 (1.4)) participated in this randomized, single-blind crossover trial. Subjects received alcohol to gain a blood alcohol concentration (BAC) of 0.05%, 0.08%, and 0.11%, or placebo-alcohol. In each condition, subjects completed a 100-km highway driving simulator test. The standard deviation of lateral position, the weaving of the car, was the primary parameter of the test. Results Alcohol produced dose-dependent driving impairment. Standard deviation of lateral position and standard deviation of speed were significantly increased relative to placebo ( p < 0.05). Subjective driving assessments were in line with the objective driving measurements. Conclusion The STISIM highway driving simulator test is able to differentiate dose-dependent impairment after administration of alcohol. The highway driving test scenario is suitable for future psychopharmacological research. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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