| Autor: |
Albarracin, Cesar A., Fuqua, Burcham C., Evans, Joseph L., Goldfine, Ira D. |
| Zdroj: |
Diabetes/Metabolism Research & Reviews; Jan2008, Vol. 24 Issue 1, p41-51, 11p |
| Abstrakt: |
Background Chromium and biotin play essential roles in regulating carbohydrate metabolism. This randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the combination of chromium picolinate and biotin on glycaemic control. Methods Four hundred and forty-seven subjects with poorly controlled type 2 diabetes (HbA1c ≥ 7.0%) were enrolled and received either chromium picolinate (600 µg Cr+3) with biotin (2 mg), or matching placebo, for 90 days in combination with stable oral anti-diabetic agents (OADs). Major endpoints were reductions in HbA1c, fasting glucose, and lipids. Safety and tolerability were assessed. Results Change in HbA1c was significantly different between treatment groups ( p = 0.03). HbA1c in the chromium picolinate/biotin group decreased 0.54%. The decrease in HbA1c was most pronounced in chromium picolinate/biotin subjects whose baseline HbA1c ≥ 10%, and highly significant when compared with placebo (−1.76% vs − 0.68%; p = 0.005). Fasting glucose levels were reduced in the entire chromium picolinate/biotin group versus placebo (−9.8 mg/dL vs 0.7 mg/dL; p = 0.02). Reductions in fasting glucose were also most marked in those subjects whose baseline HbA1c ≥ 10.0%, and significant when compared to placebo (−35.8 mg/dL vs. 16.2 mg/dL; p = 0.01). Treatment was well tolerated with no adverse effects dissimilar from placebo. Conclusions These results suggest that the chromium picolinate/biotin combination, administered as an adjuvant to current prescription anti-diabetic medication, can improve glycaemic control in overweight to obese individuals with type 2 diabetes; especially those patients with poor glycaemic control on oral therapy. Copyright © 2007 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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