| Autor: |
Querfeld, C., Sollberg, S., Huerkamp, C., Eckes, B., Krieg, T. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Jun2000, Vol. 142 Issue 6, p1228-1233, 6p, 4 Color Photographs |
| Abstrakt: |
Pseudoscleroderma as a paraneoplastic syndrome is a rare disease. We report here a patient with lung cancer (undifferentiated squamous cell carcinoma), who developed acrosclerosis. Using in situ hybridization, marked expression of α1(I)-collagen and connective tissue growth factor (CTGF) mRNA was found in fibroblasts scattered throughout the dermis. However, transforming growth factor (TGF)-β1 expression was not detected. The pattern of CTGF gene expression and collagen synthesis was similar to that in systemic scleroderma. The absence of TGF-β1 mRNA could indicate that tumour-derived factors induce the expression of CTGF. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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