| Autor: |
Singh, Varun Pratap, Ramu., Dinesh Mysore, Amarnath, B. C., Dharma, R. M., Chikanayaka, Prashanth, Shetty, Akshai |
| Předmět: |
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| Zdroj: |
American Journal of Biomedical Sciences; Jul2011, Vol. 3 Issue 3, p236-240, 5p |
| Abstrakt: |
Introduction: Non Syndromic Cleft lip/Palate is a common congenital anomaly with significant medical, psychological, social and economic ramifications. It is an example of complex genetic trait. There is sufficient evidence to hypothesize that disease locus for this condition can be identified by candidate genes. The purpose of this study was to test whether TGFB3 rs2300607 (IVSI+ 5321) gene variant was involved in the etiology of Non Syndromal Cleft lip/Palate. Materials and methods: Blood samples were collected with informed consent from 25 subjects having Non Syndromic Cleft lip/Palate and 25 controls .Genomic DNA was extracted from the blood samples, Polymerase Chain Reaction was performed (PCR) and digestion products were evaluated. Results: The Results showed a positive correlation between TGFB3 rs2300607 (IVSI+ 5321) variant and Non Syndromal Cleft lip/Palate patients. Conclusion: TGFB3 rs2300607 (IVSI+ 5321) gene variant may be a good screening marker for Non Syndromal Cleft lip /Palate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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