| Autor: |
Nakayama, Emi E., Meyer, Laurence, Iwamoto, Aikichi, Persoz, Anne, Nagai, Yoshiyuki, Rouzioux, Christine, Delfraissy, Jean-François, Debre, Patrice, McIlroy, Dorian, Theodorou, Ioannis, Shioda, Tatsuo |
| Předmět: |
|
| Zdroj: |
Journal of Infectious Diseases; 4/15/2002, Vol. 185 Issue 8, p1183, 4p, 1 Chart, 3 Graphs |
| Abstrakt: |
The interleukin (IL)-4 --589T allele bears a single nucleotide polymorphism at position --589 upstream from the open-reading frame of the IL-4 gene. To determine the influence of this allele on human immunodeficiency virus (HIV) type 1 disease, disease progression and serum virus load were assessed by IL-4 genotype in 427 white patients with known seroconversion dates who were followed in the French SEROCO cohort between 1988 and 1996. Serum virus load was 0.20 log lower during the 6-24-month plateau phase after seroconversion in patients with IL-4 --589T than in those without this allele (P = .02). Kaplan-Meier analysis survival curves showed a slower progression to clinical AIDS in carriers of IL-4 --589T (P = .04). Adjustment for early serum virus load greatly diminished the strength of this association. These results suggest that IL-4 --589T protects against HIV-1 disease progression by reducing virus load. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
