Cytotoxic lignans from the stems of Helicteres hirsuta collected in indonesia.

Autor: Chin, Young-Won, Jones, William P., Rachman, Ismail, Riswan, Soedarsono, Kardono, Leonardus B.S., Chai, Hee-Byung, Farnsworth, Norman R., Cordell, Geoffrey A., Swanson, Steven M., Cassady, John M., Kinghorn, A. Douglas
Zdroj: Phytotherapy Research; Jan2006, Vol. 20 Issue 1, p62-65, 4p
Abstrakt: Cytotoxicity-guided fractionation of the stems of Helicteres hirsuta, of Indonesian origin, led to the isolation and identification of six lignans, namely, (±)-pinoresinol, (±)-medioresinol, (±)-syringaresinol, (−)-boehmenan, (−)-boehmenan H and (±)- trans-dihydrodiconiferyl alcohol. Of these isolates, (±)-pinoresinol exhibited potent cytotoxic effects when evaluated against a small panel of cancer cell lines. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index