| Autor: |
Lee, Seung-Cheol, Poptani, Harish, Pickup, Stephen, Jenkins, W. Timothy, Kim, Sungheon, Koch, Cameron J., Delikatny, E. James, Glickson, Jerry D. |
| Zdroj: |
NMR in Biomedicine; Jul2010, Vol. 23 Issue 6, p624-632, 9p |
| Abstrakt: |
The purpose of the study was to investigate the capability of 1H MRS and MRI methods for detecting early response to radiation therapy in non-Hodgkin's lymphoma (NHL). Studies were performed on the WSU-DLCL2 xenograft model in nude mice of human diffuse large B-cell lymphoma, the most common form of NHL. Radiation treatment was applied as a single 15 Gy dose to the tumor. Tumor lactate, lipids, total choline, T2 and apparent diffusion coefficients (ADC) were measured before treatment and at 24 h and 72 h after radiation. A Hadamard-encoded slice-selective multiple quantum coherence spectroscopy sequence was used for detecting lactate (Lac) while a stimulated echo acquisition mode sequence was used for detection of total choline (tCho) and lipids. T 2- and diffusion-weighted imaging sequences were used for measuring T 2 and ADC. Within 24 h after radiation, significant changes were observed in the normalized integrated resonance intensities of Lac and the methylenes of lipids. Lac/H2O decreased by 38 ± 15% ( p = 0.03), and lipid (1.3 ppm, CH2)/H2O increased by 57 ± 14% ( p = 0.01). At 72 h after radiation, tCho/H2O decreased by 45 ± 14% ( p = 0.01), and lipid (2.8 ppm, polyunsaturated fatty acid)/H2O increased by 970 ± 36% ( p = 0.001). ADC increased by 14 ± 2% ( p = 0.003), and T 2 did not change significantly. Tumor growth delay and regression were observed thereafter. This study enabled comparison of the relative sensitivities of various 1H MRS and MRI indices to radiation and suggests that 1H MRS/MRI measurements detect early responses to radiation that precede tumor volume changes. Copyright © 2010 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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