| Autor: |
Nicholson, W. M., Beard, M. E. J., Crowther, D., Stansfeld, A. G., Vartan, C. P., Malpas, J. S., Fairley, G. Hamilton, Scott, Ronald Bodley |
| Zdroj: |
British Medical Journal; 7/4/1970, Vol. 3 Issue 5713, p7-10, 4p, 4 Charts, 3 Graphs |
| Abstrakt: |
Fifty-two patients with generalized Hodgkin's disease were treated with a combination of mustine hydrochloride, vinblastine, procarbazine, and prednisolone. Complete remissions were obtained initially in six out of seven patients (86%) who had previously received no treatment, in 15 out of 19 (79%) who had had only radiotherapy in the past, and in 9 out of 26 (35%) who had previously been given chemotherapy with or without radiotherapy. Of these 30 patients in whom a complete remission was obtained 22 have been free of any symptoms or signs of disease for periods ranging from 4 to 22 months. The response to treatment was rapid, and toxicity was not a major problem, except in those who had previously been treated with cytotoxic drugs used continuously and not in courses. A comparative trial of radiotherapy and combination therapy in the treatment of Stage III Hodgkin's disease is strongly recommended. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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