| Autor: |
Polska, Elzbieta, Doelemeyer, Arno, Luksch, Alexandra, Ehrlich, Paulina, Kaehler, Nils, Percicot, Christine L., Lambrou, George N., Schmetterer, Leopold |
| Předmět: |
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| Zdroj: |
Archives of Ophthalmology; Mar2002, Vol. 120 Issue 3, p348, 5p |
| Abstrakt: |
Background: There is increasing evidence that reduced ocular blood flow plays a role in the pathogenesis of glaucoma. In patients with normal-tension glaucoma, ocular blood flow abnormalities may be associated with dysfunction of the endothelin 1 (ET-1) regulation system. Objective: To test the hypothesis that unoprostone, a topical docosanoid, may affect ET-1-induced vasoconstriction in the human choroid. Methods: In a placebo-controlled, randomized, doublemasked, 2-way crossover design, ET-1 (2.5 ng/kg per minute for 150 minutes) was administered intravenously to 24 healthy individuals. Thirty minutes after the start of ET-1 infusion, 1 drop of unoprostone or placebo was instilled into the right eye. After another 30 minutes, 2 drops of unoprostone or placebo was topically administered. This procedure was continued and the dose was increased further until 4 drops of unoprostone or placebo was reached. Subfoveal and pulsatile choroidal blood flow were assessed using laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude, respectively. Results: Administration of exogenous ET-1 decreased choroidal blood flow (mean ± SEM, 17% ± 2%; P<.001) and fundus pulsation amplitude (mean ± SEM, 19% ± 2%; P<.001). This effect was significantly blunted when topical unoprostone was coadministered (mean ± SEM decrease in choroidal blood flow, 7% ± 2%; P = .04 vs placebo; mean ± SEM decrease in fundus pulsation amplitude, 12% ± 2%; P<.001 vs placebo). Conclusion: There is a functional antagonism between ET-1 and topical unoprostone in the choroidal vasculature. Clinical Relevance: Our findings of a functional antagonism between ET-1 and topical unoprostone in the choroidal vasculature may be important in vascular eye diseases associated with increased ET-1. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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