Lung Recruitment Maneuver during Volume Guarantee Ventilation of Preterm Infants with Acute Respiratory Distress Syndrome.

Autor: Castoldi, Francesca, Daniele, Irene, Fontana, Paola, Cavigioli, Francesco, Lupo, Enrica, Lista, Gianluca
Předmět:
Zdroj: American Journal of Perinatology; 2011, Vol. 28 Issue 7, p521-527, 7p, 2 Charts, 3 Graphs
Abstrakt: Preterm infants need the achievement of adequate lung volume. Lung recruitment maneuver (LRM) is applied during high-frequency oscillatory ventilation. We investigated the effect of an LRM with positive end-expiratory pressure (PEEP) on oxygenation and outcomes in infants conventionally ventilated for respiratory distress syndrome (RDS). Preterm infants in assisted controlled ventilationþvolume guarantee for RDS after surfactant randomly received an LRM (group A) or did not (group B). LRM entailed increments of 0.2 cm H2O PEEP every 5 minutes, until fraction of inspired oxygen (FiO2)=0.25. Then PEEP was reduced and the lung volume was set on the deflation limb of the pressure/volume curve. When saturation of peripheral oxygen fell and FiO2 rose, we reincremented PEEP until SpO2 became stable. Group A (n=10) and group B (n=10) infants were similar: gestational age 25±2 versus 2±52 weeks; body weight 747±233 versus 737±219 g; clinical risk index for babies 9.8 versus 8.1; initial FiO2 56±24 versus 52±21, respectively. LRM began at 86±69 minutes of age and lasted for 61±18 minutes. Groups A and B showed different max PEEP during the first 12 hours of life (6.1±0.3 versus 5.3±0.3 cm H2O, p=0.00), time to lowest FiO2 (94±24 versus 435±221 minutes; p=0.000) and O2 dependency (29±12 versus 45±17 days; p=0.04). No adverse events and no differences in the outcomes were observed. LRM led to the earlier lowest FiO2 of the first 12 hours of life and a shorter O2 dependency. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: