| Autor: |
Corti, Marcelo, Villafañe, Maria, Solari, Ruben, Carolis, Luis, Cangelosi, Diana, Santoro, Jose, Schtirbu, Ricardo, Lewi, Daniel, Bistmans, Alicia, Narbaitz, Marina, Baré, Patricia |
| Zdroj: |
Journal of Gastrointestinal Cancer; Sep2011, Vol. 42 Issue 3, p143-148, 6p |
| Abstrakt: |
Introduction: Extranodal non-Hodgkin lymphoma (NHL) were commonly described in AIDS patients and are related with an atypical morphology and aggressive clinical course. Materials and Methods: In this single institutional study we evaluated the epidemiological, clinical, immunological, virological, histopathological and the outcome of eleven HIV/AIDS patients with oral cavity lymphomas (OCL). Results: Nine were males and seven intravenous drug abusers. The median of age was 33 years and the median of CD4 T cell counts at the time of diagnosis was 97 cell/µL. The majority of tumors presented as large and ulcerated masses involving the gingiva, the palate and the jaw. Six of these tumors were diffuse large B-cell lymphomas (DLBCL); three were Burkitt's lymphomas and the final case was a plasmablastic lymphoma. An association with Epstein-Barr virus (EBV) was found in three of the ten tested cases by in situ hybridization (EBER 1 and 2 probes) and immunohistochemistry (LMP-1). Human herpes virus-8 (HHV-8) was detected by polymerase chain reaction (PCR) in only one neoplasm. Six patients died without specific treatment; four received chemotherapy and highly active antiretroviral therapy (HAART) and three of them presented a prolonged survival. Discussion: Combination of HAART and chemotherapy should modify the poor prognosis of AIDS patients with OCL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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