129Xe spectra from the heads of rats with and without ligation of the external carotid and pterygopalatine arteries.

Autor: Nakamura, Kazuhiro, Kondoh, Yasushi, Wakai, Atsushi, Kershaw, Jeff, Wright, David, Kanno, Iwao
Zdroj: Magnetic Resonance in Medicine; Mar2005, Vol. 53 Issue 3, p528-534, 7p
Abstrakt: After rats inhaled hyperpolarized 129Xe gas, in vivo spectra from their heads revealed a dominant peak around 195 ppm, another easily resolvable peak near 189 ppm, a broad peak around 210 ppm, and two minor peaks around 198 ppm and 192 ppm. However, the source of each peak remains controversial. To further study the origin of each peak, we compared spectra obtained from the heads of normal rats with spectra taken from the heads of rats that had undergone ligation of the external carotid (ECA) and pterygopalatine (PPA) arteries, the major feeding vessels of nonbrain tissue in the rat head. The amplitude of the peak at around 189 ppm was greatly reduced in the ECA/PPA-ligated rats, while the peak around 195 ppm persisted. We conclude that the signal that originates from the rat brain after inhalation of 129Xe gas is overwhelmingly dominated by the single resonance at 195 ppm. Magn Reson Med 53:528-534, 2005. © 2005 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index