| Autor: |
Bax, Noortje A.M., Lie-Venema, Heleen, Vicente-Steijn, Rebecca, Bleyl, Steven B., Van Den Akker, Nynke M.S., Maas, Saskia, Poelmann, Robert E., Gittenberger-de Groot, Adriana C. |
| Zdroj: |
Developmental Dynamics; Oct2009, Vol. 238 Issue 10, p2658-2669, 12p |
| Abstrakt: |
For the establishment of a fully functional septated heart, addition of myocardium from second heart field-derived structures is important. Platelet-derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role of PDGF-A, PDGF-C, and their receptor PDGFR-α. We analyzed the expression patterns of PDGF-A, -C, and their receptor PDGFR-α during avian heart development. A spatiotemporal pattern of ligands was seen with colocalization of the PDGFR-α. This was found in second heart field-derived myocardium as well as the proepicardial organ (PEO) and epicardium. Mechanical inhibition of epicardial outgrowth as well as chemical disturbance of PDGFR-α support a functional role of the ligands and the receptor in cardiac development. Developmental Dynamics 238:2658-2669, 2009. © 2009 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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