| Autor: |
Houwelingen, Marc, Merkus, Daphne, te Lintel Hekkert, Maaike, Dijk, Geert, Hoeks, Arnold, Duncker, Dirk |
| Předmět: |
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| Zdroj: |
Medical & Biological Engineering & Computing; Aug2011, Vol. 49 Issue 8, p917-924, 8p, 1 Chart, 4 Graphs |
| Abstrakt: |
In earlier work, we suggested that the start of the isovolumic contraction period could be detected in arterial pressure waveforms as the start of a temporary pre-systolic pressure perturbation (AIC, start of the Arterially detected Isovolumic Contraction), and proposed the retrograde coronary blood volume flow in combination with a backwards traveling pressure wave as its most likely origin. In this study, we tested this hypothesis by means of a coronary artery occlusion protocol. In six Yorkshire × Landrace swine, we simultaneously occluded the left anterior descending (LAD) and left circumflex (LCx) artery for 5 s followed by a 20-s reperfusion period and repeated this sequence at least two more times. A similar procedure was used to occlude only the right coronary artery (RCA) and finally all three main coronary arteries simultaneously. None of the occlusion protocols caused a decrease in the arterial pressure perturbation in the aorta during occlusion ( P > 0.20) nor an increase during reactive hyperemia ( P > 0.22), despite a higher deceleration of coronary blood volume flow ( P = 0.03) or increased coronary conductance ( P = 0.04) during hyperemia. These results show that the pre-systolic aortic pressure perturbation does not originate from the coronary arteries. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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