| Autor: |
Swami, Srilatha, Krishnan, Aruna V., Moreno, Jacqueline, Bhattacharyya, Rumi S., Gardner, Christopher, Brooks, James D., Peehl, Donna M., Feldman, David |
| Zdroj: |
International Journal of Cancer; May2009, Vol. 124 Issue 9, p2050-2059, 10p |
| Abstrakt: |
Soy and its constituent isoflavone genistein inhibit the development and progression of prostate cancer (PCa). Our study in both cultured cells and PCa patients reveals a novel pathway for the actions of genistein, namely the inhibition of the synthesis and biological actions of prostaglandins (PGs), known stimulators of PCa growth. In the cell culture experiments, genistein decreased cyclooxygenase-2 ( COX-2) mRNA and protein expression in both human PCa cell lines (LNCaP and PC-3) and primary prostate epithelial cells and increased 15-hydroxyprostaglandin dehydrogenase (15-PGDH) mRNA levels in primary prostate cells. As a result genistein significantly reduced the secretion of PGE [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text