| Autor: |
Visser, Jeroen, van Baarle, Debbie, Hoogeboom, Baukje Nynke, Reesink, Nathalie, Klip, Harry, Schuuring, Ed, Nijhuis, Esther, Pawlita, Michael, Bungener, Laura, de Vries-Idema, Jacqueline, Nijman, Hans, Miedema, Frank, Daemen, Toos, van der Zee, Ate |
| Zdroj: |
International Journal of Cancer; May2006, Vol. 118 Issue 10, p2529-2537, 9p |
| Abstrakt: |
It has been suggested that local invasive procedures may alter the natural course of (pre)malignant cervical disease. This could be due to partial excision of the lesions, or via induction of cellular immunity against human papillomavirus (HPV) by the local invasive procedures. We studied the influence of local invasive procedures on HPV-16 E7 specific immune responses in patients with different grades of cervical intra-epithelial neoplasia (CIN) and different stages of cervical cancer. Blood was obtained at intake and after invasive procedures from patients with CIN or cervical cancer. Antigen specific T-cell responses were measured by IFN-γ ELISPOT analysis, after stimulation with recombinant HPV-16 E7 protein. As expected, HPV-16 E7 specific IFN-γ T cell responses were more frequent in HPV-16 DNA positive patients compared with that in HPV-16 DNA negative patients (39/50 vs. 16/36, ( p = 0.006, χ [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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