Imiquimod-induced clearance of HPV is associated with normalization of immune cell counts in usual type vulvar intraepithelial neoplasia.

Autor: Terlou, Annelinde, Seters, Manon van, Kleinjan, Alex, Heijmans-Antonissen, Claudia, Santegoets, Lindy A.M., Beckmann, Ilse, Beurden, Marc van, Helmerhorst, Theo J.M., Blok, Leen J.
Zdroj: International Journal of Cancer; Dec2010, Vol. 127 Issue 12, p2831-2840, 10p
Abstrakt: Recently, we reported on the efficacy of imiquimod for treatment of usual type vulvar intraepithelial neoplasia (uVIN). A histologic regression of uVIN to normal tissue was observed in 58% of patients. As success of treatment is related to clearance of high-risk human papilloma virus (HPV), the aim of our study was to assess differences in immune cell counts and in the expression of p16 [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index