| Autor: |
Tresoldi, Eleonora, Romiti, Maria Luisa, Boniotto, Michele, Crovella, Sergio, Salvatori, Francesca, Palomba, Elvia, Pastore, Angela, Cancrini, Caterina, de Martino, Maurizio, Plebani, Anna, Castelli, Guido, Rossi, Paolo, Tovo, Pier Angelo, Amoroso, Antonio, Scarlatti, Gabriella |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 3/1/2002, Vol. 185 Issue 5, p696, 5p |
| Abstrakt: |
A mutation of the stromal cell-derived factor 1 gene (SDF-1 3'A) was shown to protect adults exposed to human immunodeficiency virus type 1 (HIV-1) from infection and to affect HIV disease progression in adults. The presence of this mutation in HIV-l-infected Kenyan children did not predict mother-to-child virus transmission. The SDF-1 3'A polymorphism was studied in 256 HIV-l-infected, 118 HIV-l-exposed but uninfected, and 170 unexposed and uninfected children of Italian origin, and the frequency of SDF-1 3'A heterozygosity and homozygosity in each of the 3 groups was similar. Of the 256 HIV-1-infected children, 194 were regularly followed up and were assigned to groups according to disease progression. The frequency of the SDF-1 3'A allele was substantially lower among children with long-term nonprogression than among children with rapid (P = .0329) or delayed (P = .0375) progression. We show that the presence of the SDF-1 3'A gene correlates with accelerated disease progression in HIV-l-infected children born to seropositive mothers but does not protect against mother-to-child HIV1 transmission. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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