| Autor: |
Spadafora-Ferreira, Mônica, Caetano Fernandes, Luciana, Pfrimer, Irmtraut Araci Hoffman, Pichiteli, Cássia Regina, Tambourgi, Denise Vilarinho, de Souza Lino-Junior, Ruy, Carvalhaes, Mara Silvia |
| Předmět: |
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| Zdroj: |
Journal of Parasitology Research; 2010, p1-8, 8p, 1 Diagram, 4 Graphs |
| Abstrakt: |
Recently, we demonstrated that C57BL/6 mice are more susceptible to experimental lagochilascariosis than BALB/c mice. To investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental lagochilascariosis in H-2a identical B10.A and A/J mice. Infected B10.A mice had a lower survival ratio and more severe lesions in the lungs than did A/J mice. Splenocytes of A/J mice immunized with the crude extract of the parasite showed increased proliferation and produced a higher level of interleukin 10 and interferon-? in the presence of CE or concanavalin A when compared to B10.A mice. This suggests that resistance of A/J mice may be due to less severe lesions in lungs and other organs and a better immune response to parasite antigens. This paper provides evidence that major histocompatibility complex haplotype does not influence the survival to experimental infection with L. minor. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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