Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes.

Autor: GRAFF, JOHANNES, DOHOON KIM, DOBBIN, MATTHEW M., Li-HUEI TSAI
Předmět:
Zdroj: Physiological Reviews; Apr2011, Vol. 91 Issue 2, p603-649, 47p
Abstrakt: The article offers information on the epigenetic mechanisms of gene expression in physiological and pathological brain processes. It states that the deregulation of epigenetic regulation has been involved in a number of neurodevelopmental disorders, including Rett Syndrome, Fragile X and Schizophrenia. It mentions that the most common neurodegenerative disorder is Alzheimer's disease as neurons are progressively lost during disease progression from the hippocampus, cortex and other regions.
Databáze: Complementary Index