| Autor: |
Dieli, Francesco, Caccamo, Nadia, Meraviglia, Serena, Ivanyi, Juraj, Sireci, Guido, Bonanno, Cesira T., Ferlazzo, Viviana, La Mendola, Carmela, Salerno, Alfredo |
| Zdroj: |
European Journal of Immunology; Nov2004, Vol. 34 Issue 11, p3227-3235, 9p |
| Abstrakt: |
γδ T cells and dendritic cells (DC) are two distinct cell types of innate immunity that participate in early phases of immune response against Mycobacterium tuberculosis infection. Here we show that a close functional relationship exists between these cell populations. Using an in vitro coculture system, Vγ1 T cells from Tcrbmice were found to be activated by DC infected in vitro with BCG, as indicated by the elevated CD69 expression, IFN-γ secretion and cytotoxic activity. This activation process was due to a non-cognate mechanism since it required neither cell to cell contact nor interaction between the TCR and a specific antigen, but was mediated by DC-derived IL-12. Reciprocally, Vγ1 T cells provided a key cytokine, IFN-γ, which increased IL-12 production by BCG-infected DC. Moreover, exposure of BCG-infected DC to Vγ1 T cells conditioned the former to prime a significantly stronger anti-mycobacterial CD8 T cell response. Consequently, stimulation of γδ T cells and their non-cognate interaction with DC could be applied as an immune adjuvant strategy to optimize vaccine-induced CD8 T cell immunity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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