| Autor: |
Höhn, Hanni, Kortsik, Cornelius, Tully, Glenn, Nilges, Katja, Necker, Antje, Freitag, Kirsten, Neukirch, Claudia, Galle, Peter, Löhr, Hans, Maeurer, Markus J. |
| Zdroj: |
European Journal of Immunology; Jun2003, Vol. 33 Issue 6, p1613-1623, 11p |
| Abstrakt: |
CD8 T cells play a central role in immune protection against infection with Mycobacterium tuberculosis. One of the target epitopes for anti- M. tuberculosis directedCD8 T cells is the HLA-A2-restricted 19-kDa lipoprotein peptide VLTDGNPPEV. T cell clones directed against this epitope recognized not only the nominal peptide ligand, but also a closely related peptide (VPTDPNPPEV) from the HIV envelope gp120 (HIV gp120) protein characterized by IFN-γ release. This cross-reactivity was confirmed in ex vivo in M. tuberculosis 19-kDa tetramer-sorted T cells from patients with tuberculosis and in HIVgp120 tetramer-reactive T cells sorted from HIV patients. M. tuberculosis 19-kDa antigen-reactive T cells were present in HLA-A2 patients (10/10) with HIV infection with no evidence of M. tuberculosis infection, but they are absent in peripheral blood lymphocytes from healthy HLA-A2 individuals (10/10). M. tuberculosis 19-kDa antigen-reactive T cells were elevated in acute pulmonary tuberculosis, declined with response to therapy (7/10 patients) and resided in the terminally differentiated CD8 T cell subset. CD8 cross-reactive T cells recognizing HIV or M. tuberculosis 19-kDa antigens may contribute to pathogenesis in individuals co-infected with both pathogens and may also present a marker for active tuberculosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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