| Autor: |
Pichler, Robert, Maschek, Wilhelmine, Krieglsteiner, Sigbert, Raml, Andreas, Schmekal, Bernhard, Berg, Jörg, Berg, Jörg |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Rheumatology; Feb2002, Vol. 31 Issue 1, p41-43, 3p |
| Abstrakt: |
Objective: As serotonin is a mediator of inflammatory joint disease, serum levels were investigated in human patients with arthritis for a possible corresponding role as a disease marker.Design: 48 patients were evaluated by bone scan for disease activity. 5-HT and CRP were measured in the whole group, and IL-6 in those not yet receiving corticosteroids. The pro-inflammatory parameters were compared to each other and to scintigraphic features.Results: The serum levels of serotonin did not correspond to disease activity measured by CRP, IL-6 or activity on joints in skeletal scintigraphy. No difference was seen in comparison to the values of a control group, but when glucocorticoid treatment was included, low 5-HT serum values were observed. A significant correlation between CRP and IL-6 as indicators of inflammation and bone scan results versus CRP could be shown.Conclusion: The measurement of serum serotonin provides no relevant information about disease activity in synovial inflammation. For monitoring osteoarthritis and synovial inflammation, bone scan and laboratory determination of CRP and IL-6 together appear to present useful information about infestation in the disease process. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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