Oxidative Additions with 1,4-Dihydropyridines: A One-Pot Synthesis of 3,4,4a,5,8,8a-Hexahydro-2H-pyrido[3,2-b][1,4]oxazine Derivatives.

Autor:	Kumar, Rakesh, Malik, Shakshi, Kumar, Dhiraj, Prasad, AshokK.
Předmět:	OXIDATIVE stress ORGANIC synthesis PIPERIDINE ELECTROPHILES BICYCLIC compounds HETEROCYCLIC compounds
Zdroj:	Synthetic Communications; 2011, Vol. 41 Issue 18, p2719-2726, 8p
Abstrakt:	[image omitted] 3,4,4a,5,8,8a-Hexahydro-2H-pyrido[3,2-b][1,4]oxazine derivatives (2a-h) are conveniently prepared in excellent yields by a one-pot synthesis from 1,4-dihydropyridines. The key transformation features an electrophilic interaction of iodine with N-alkyl-1,4-dihydropyridine (1a-d) in the presence of a nucleophile diethanol amine or N-methylethanol amine, stereoselectively leading to the corresponding bicyclic heterocycles (2a-h). [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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