| Autor: |
Seet, Robert A., Hamilton, Ronald L., Healy, Matthew T., Wisniewski, Stephen R., Henteleff, Ruth, Pollock, Bruce G., Lewis, David A., DeKosky, Steven T. |
| Předmět: |
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| Zdroj: |
Archives of Neurology; Mar2001, Vol. 58 Issue 3, p466, 7p |
| Abstrakt: |
Background: Lewy bodies (LB) are present in at least 20% to 30% of persons with Alzheimer disease (AD) and contribute to the risk of psychosis and to excess cogni-tive burden. Objective: To determine whether altered striatal do-pamine receptor binding is associated with LB and psy-chosis in AD. Design: Postmortem case control. Setting: Alzheimer's Disease Research Center at the Uni-versity of Pittsburgh (Pa). Participants: Consecutive cases from the Alzheimer's Disease Research Center brain bank, neuroleptic free for at least 1 month prior to death, with neuropathologic di-agnoses of AD with LB (AD+LB, n=14), AD without LB (AD, n=13), or normal brains (n=8). Main Outcome Measures: Dopamine D&sub1;,D&sub2;, and D&sub3;. receptor densities, and affinities as determined by selec-tive saturation binding studies in striatal tissue. Results: Subjects with AD+LB, compared with those with AD, demonstrated increased D1 receptor density and de-creased D&sub2; and D&sub3; receptor density. D&sub3; receptor density was selectively increased, however, in AD subjects with a history of psychosis, independent of the presence or absence of LB. The effect of neuroleptic treatment on D3 binding was further examined in an additional group of subjects who had received neuroleptics near the time of death. Neuroleptic treatment reduced D&sub3; affinity with no effect on D&sub3; density. Conclusions: Alzheimer disease with LB is associated with selective alterations in dopamine receptor density, which may contribute to the distinct clinical profile of this group. The D&sub3; receptor may be an important target of neuroleptic treatment of psychosis in AD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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