| Autor: |
Goetz, Christopher G., Burke, Paul F., Leurgans, Sue, Berry-Kravis, Elizabeth, Blasucci, Lucy M., Raman, Rema, Zhou, Lili |
| Předmět: |
|
| Zdroj: |
Archives of Neurology; Feb2001, Vol. 58 Issue 2, p209, 5p |
| Abstrakt: |
Background: Visual hallucinations in Parkinson disease (PD) occur in approximately one third of patients treated long-term with dopaminergic medications. In Alzheimer disease, hallucinations and psychosis have been linked to increased representations of B2/B2 homozyogotes for the dopamine receptor gene DRD1 and 1/1 or 2/2 homozygotes for DRD3. In addition, a previous study of PD patients with and without hallucinations did not show differences in D2 and D3 polymorphisms, although careful case-control matching was not performed. Another study linked the apolipoprotein E4 (APOE4) allele to hallucinations in PD. Objective: To determine whether the frequency of dopamine receptor genetic variants and APOE alleles in patients with PD with and without chronic visual hallucinations resembles the pattern previously documented in patients with Alzheimer disease. Methods: We conducted a case-control study of 44 patients with PD and chronic hallucinations and 44 patients with PD who had never hallucinated. Cases and controls were matched for current age and medications. DNA was isolated from blood samples and assayed for DRD1, DRD2, DRD3, DRD4, and APOE polymorphisms. Receptor polymorphisms were genotyped by polymer-ase chain reaction. Genotypes in hallucinators and non-hallucinators were compared using Mantel-Haenszel tests... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
