| Autor: |
Rivera, Constantino Fernández, Hernández, Ángel Alonso, Reboredo, Juan Mosquera, Gómez, Ignacio Rodríguez |
| Předmět: |
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| Zdroj: |
NDT Plus; Jun2010, Vol. 3 Issue 3, p300-302, 3p, 2 Color Photographs |
| Abstrakt: |
Viral infection has been related to post-transplantation tumour development, particularly Epstein–Barr virus, human papillomavirus, hepatitis B and C viruses, and herpes virus 8. Recently, BK virus (BKV) has emerged as an important cause of tumour formation in solid organ transplant recipients. BKV oncogenic potential relates to the ability to inactivate the functions of tumour suppression proteins p53 and pRB family, and induction of chromosomal aberrations. We report a case of urinary bladder adenocarcinoma in a pancreatico-renal transplant recipient which was diagnosed 2 years after BKV infection. Immunohistochemical staining for SV-40 was positive in neoplastic cells but negative in non-neoplastic cells. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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