| Autor: |
Bonnardot, Laurent, Bardet, Etienne, Steichen, Olivier, Cassagnau, Elisabeth, Piot, Benoit, Salam, Alex P., Campion, Loïc, Ferron, Christophe, Beauvillain de Montreuil, Claude, Malard, Olivier |
| Předmět: |
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| Zdroj: |
Head & Neck; Jul2011, Vol. 33 Issue 7, p928-934, 7p, 3 Charts, 1 Graph |
| Abstrakt: |
Background. The aim of this study was to identify factors predicting poor prognosis at the time of early oral tongue carcinoma diagnosis. Methods. A retrospective cohort study was carried out on 70 patients with T1 or T2 squamous cell carcinoma of the mobile tongue treated with primary surgical treatment. Results. In all, 47% of patients received adjuvant treatment. Local recurrence was observed in 29% and regional recurrence in 26%. With a median follow-up of 7.3 years for living patients, 5-year actuarial overall, disease-specific, and disease-free survival rates were 48%, 61%, and 42%, respectively. The presence of poor histological differentiation increased the overall risk of death. Tumor thickness and posterior lingual location independently increased overall and disease-specific risk of death. Concurrent or previous diagnosis of oral lichen significantly increased the risk of disease-specific death and disease recurrence. Conclusions. This study corroborates several known prognostic factors and indicates that diagnosis of oral lichen planus may be a risk factor for disease recurrence. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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