| Autor: |
Deepak, Vishwa, Zhang, Zhongli, Meng, Lingyi, Zeng, Xianlu, Liu, Wenguang |
| Zdroj: |
Cell Biochemistry & Function; Jun2011, Vol. 29 Issue 4, p348-350, 1p |
| Abstrakt: |
Tbox3, a T-box containing transcription factor, has been reported to negatively regulate osteoblastogenesis. Here, we studied the effects mediated by Tbx3 on the master osteogenic transcription factor Runx2 in C3h10t1/2 cells. Dual-luciferase assay results showed that Tbx3 interferes in the Runx2-mediated activation of osteopontin promoter by abrogating Runx2 activity. Immunofluorescence study demonstrated that Runx2 was simultaneously localized in the nucleus and the cytoplasm of Tbx3-overexpressing cells. The results obtained in this study indicate that Tbx3 abrogates Runx2 activity and elevated expression levels of Tbx3 in the cells can result in mislocalization of Runx2. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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