Differentiation and Clonality of Lesional Lymphocytes in Pityriasis Lichenoides Chronica.

Autor: Shieh, Sherry, Mikkola, Debra L., Wood, Gary S.
Předmět:
Zdroj: Archives of Dermatology; Mar2001, Vol. 137 Issue 3, p305, 4p
Abstrakt: Background: Pityriasis lichenoides chronica (PLC) and pityriasis lichenoides et varioliformis acuta (PLEVA) are benign T-cell diseases that share several overlapping clinicopathologic features, leading many to believe that they exist as a spectrum rather than as single entities. Previous molecular studies have shown that PLEVA is a clonal lymphoproliferative disorder. To further characterize the immunohistologic features of PLC and to determine whether PLC demonstrates clonality, we studied 6 cases of PLC using a frozen section-immunoperoxidase technique and polymerase chain reaction/denaturing gradient gel electrophoresis. Observations: All 6 cases showed a mild to moderate superficial and deep perivascular infiltrate composed predominantly of CD4[sup +] T cells, admixed with Langerhans cells and macrophages; most were associated with an HLA-DR[sup +] epidermis. Three of 6 cases involved monoclonal T-cell receptor gamma (TCRγ) gene rearrangements detected by Vγl-8/Jγl-2 and Vγ9/Jγl-2 primers. Conclusions: Our findings enhance existing data showing that PLC shares many immunohistologic features with PLEVA and indicating that PLC is frequently a clonal T-cell disease. This provides further evidence that PLC and PLEVA are interrelated processes within the larger group of T-cell lymphoproliferative disorders. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index