| Autor: |
Haas, Anna, Rehr, Manuela, Graw, Frederik, Rusert, Peter, Bossart, Walter, Kuster, Herbert, Trkola, Alexandra, Günthard, Huldrych F., Oxenius, Annette |
| Zdroj: |
EMBO Molecular Medicine; Jun2010, Vol. 2 Issue 6, p231-244, 14p |
| Abstrakt: |
Hyperactivation of CD4+ T cells is a hallmark of untreated HIV-1 infection. The antigenic specificities of activated CD4+ T cells and the underlying mechanisms leading to their activation remain thus far elusive. We report here that during HIV rebound the dynamics of HIV-specific CD4+ T cells is highly correlated with the dynamics of CD4+ T cells specific for persistent antigens derived from various members of the herpes virus family, whereas CD4 responses towards non-persistent antigens were unaffected by HIV replication. Notably, the dynamics of HIV and herpes viral antigen-specific CD4+ T cells responses correlated with the expression level of activation markers on dendritic cells (DCs) and activated DCs were more potent in restimulating memory T cells. These data strongly suggest that HIV replication costimulates activation of CD4+ T cells specific for persistent herpes viral antigens via activation of DCs. We propose that a large proportion of activated T cells during untreated HIV infection may be specific for herpes viral antigens and identify a novel mechanism contributing to chronic immune activation in untreated HIV-1 infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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