| Autor: |
Cai-Huan Huang, Jia-Hui Pan, Bin Chen, Miao Yu, Hong-Bo Huang, Xun Zhu, Yong-Jun Lu, Zhi-Gang She, Yong-Cheng Lin |
| Zdroj: |
Marine Drugs; May2011, Vol. 9 Issue 5, p832-843, 12p |
| Abstrakt: |
Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 μM. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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