| Autor: |
Lobbes, M. B. I., Kooi, M. E., Lutgens, E., Ruiters, A. W., Passos, V. Lima, Braat, S. H. J. G., Rousch, M., Cate, H. Ten, van Engelshoven, J. M. A., Daemen, M. J. A. P., Heeneman1, S. |
| Zdroj: |
International Journal of Vascular Medicine; 2010, p1-9, 9p, 3 Charts, 2 Graphs |
| Abstrakt: |
We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP,MPO, and PAPP-A were significantly increased in patients with acutemyocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
