| Autor: |
Sun-Jung Song, Kyoung Woon Jung, Yu Jeong Park, Jun Park, Myung Duck Cho, Myung Ho Jeong, Yong Sook Kim, Dong Lyun Cho |
| Zdroj: |
Journal of Materials Chemistry; Jun2011, Vol. 21 Issue 22, p8169-8177, 9p |
| Abstrakt: |
Nitrogen doped-TiO2thin film was deposited by plasma enhanced chemical vapour deposition (PECVD) process and its applicability as a drug-binding matrix was investigated in the preparation of drug eluting stents. N–TiO2film was deposited at 5 W and uniformly covered metallic stent surfaces. Films showed excellent mechanical stability and good adhesion. Alpha lipoic acid, heparin, and abciximab could then be grafted onto the N–TiO2film through ester bond formation after water plasma modification of the films' surfaces. Drug-grafted N–TiO2films showed smooth surfaces and good blood compatibility in in vitroplatelet adhesion tests. The films maintained uniform coverings, without peeling, even after expansion by a balloon catheter. Grafted-heparin and abciximab could be released continuously for three weeks from drug-grafted N–TiO2stents in in vitrodrug release test. Such immunosuppressive and antiproliferative drug-grafted N–TiO2film is expected to minimize potential problems related to organic polymers and the risk of direct contact of a bare metal surface with a blood vessel. Hence, the N–TiO2films prepared in this study are promising alternatives to organic polymers for the preparation of drug-eluting stents. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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