| Autor: |
Biswas, Devadrita, Vettriselvi, V., Choudhury, Jnankumar, Jothimalar, R. |
| Zdroj: |
Indian Journal of Clinical Biochemistry; Apr2011, Vol. 26 Issue 2, p172-177, 6p |
| Abstrakt: |
Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type 2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T > G of adiponectin gene and type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with 75 apparently healthy controls. The genotype frequency of SNP45 T > G in exon 2 of adiponectin gene was determined by PCR based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC↓GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp) and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T > G and type 2 diabetes in the study population ( P = 0.010, OR = 3.797, 95% CI = 1.312-10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for type 2 diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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