| Autor: |
Tianjie Li, Xiaopan Wu, Xilin Zhu, Jingyun Li, Liping Pan, Pengtao Li, Zhenhui Xin, Ying Liu |
| Zdroj: |
Molecular & Cellular Biochemistry; Jul2011, Vol. 353 Issue 1/2, p259-265, 7p, 5 Charts |
| Abstrakt: |
The hepatocyte nuclear factor 4-alpha ( HNF4A) and human forkhead box O1 ( FOXO1) genes have been discovered to be associated with type 2 diabetes (T2D) in different populations. This study aimed to evaluate the association between HNF4A and FOXO1 genetic polymorphisms and type 2 diabetes in the Chinese Han population. Five hundred and seventy-seven patients with type 2 diabetes and 462 normal controls were enrolled in this study. Six single-nucleotide polymorphisms (SNPs) in HNF4A and seven in FOXO1 were selected and genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or TaqMan technology. Single-locus analyses indicated that the C allele of rs11574736 from HNF4A had a lower frequency in the case group compared with the control group ( P = 0.005, OR = 0.74, 95% CI = 0.59-0.92). The genotype distributions of rs11574736 also differed between the two groups ( P = 0.02). However, none of the FOXO1 SNPs showed any association with type 2 diabetes in the Chinese Han population. Further analysis suggested the two genes interact with each other (rs3908773/rs717247/rs6031587/rs11574736: P < 0.0001, testing accuracy = 0.55, CV consistency = 6/10). In conclusion, this study shows an association between the HNF4A gene and type 2 diabetes in the Chinese Han population. Moreover, the authors confirmed the results of previous studies for the interaction between HNF4A and FOXO1 in the pathogenesis of type 2 diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink