| Autor: |
Penna, Elisa, Orso, Francesca, Cimino, Daniela, Tenaglia, Enrico, Lembo, Antonio, Quaglino, Elena, Poliseno, Laura, Haimovic, Adele, Osella-Abate, Simona, De Pittà, Cristiano, Pinatel, Eva, Stadler, Michael B, Provero, Paolo, Bernengo, Maria Grazia, Osman, Iman, Taverna, Daniela |
| Předmět: |
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| Zdroj: |
EMBO Journal; 5/18/2011, Vol. 30 Issue 10, p1990-2007, 18p |
| Abstrakt: |
Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that coordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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